Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) Peptide
KCNN3
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN978827
Aperçu rapide pour Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) Peptide (ABIN978827)
Antigène
KCNN3
(Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-KCNN3 antibody (Catalog #: ARP35441_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- KCNN3 (Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))
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Sujet
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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by KCNN3 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN3 contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions.
Alias Symbols: SK3, hSK3, SKCA3, KCa2.3
Protein Size: 426 -
Poids moléculaire
- 47 kDa
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ID gène
- 3782
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NCBI Accession
- NM_170782, NP_740752
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UniProt
- Q8WXG7
Antigène
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